Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

Abstract Background Triple negative breast cancer (TNBC) is an aggressive disease characterized by high risk of relapse and development of resistance to different chemotherapy agents. Several targeted therapies have been investigated in TNBC with modest results in clinical trials. Among these, PI3K/...

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Bibliographic Details
Main Authors: Stefania Cocco, Alessandra Leone, Maria Serena Roca, Rita Lombardi, Michela Piezzo, Roberta Caputo, Chiara Ciardiello, Susan Costantini, Francesca Bruzzese, Maria José Sisalli, Alfredo Budillon, Michelino De Laurentiis
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Translational Medicine
Subjects:
Breast Cancer
TNBC
Autophagy
PI3K/AKT/mTOR inhibitors
Chloroquine
Online Access:https://doi.org/10.1186/s12967-022-03462-z

Internet

https://doi.org/10.1186/s12967-022-03462-z

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