Regulation of chromatin microphase separation by binding of protein complexes

Regulation of chromatin microphase separation by binding of protein complexes

We show evidence of the association of RNA polymerase II (RNAP) with chromatin in a core-shell organization, reminiscent of microphase separation where the cores comprise dense chromatin and the shell, RNAP and chromatin with low density. These observations motivate our physical model for the regula...

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Bibliographic Details
Main Authors: Omar Adame-Arana, Gaurav Bajpai, Dana Lorber, Talila Volk, Samuel Safran
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
chromatin organization
microphase separation
chromatin-binding protein complexes
active and inactive chromatin
Online Access:https://elifesciences.org/articles/82983

Internet

https://elifesciences.org/articles/82983

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