An improved DNA-binding hot spot residues prediction method by exploring interfacial neighbor properties

An improved DNA-binding hot spot residues prediction method by exploring interfacial neighbor properties

Abstract Background DNA-binding hot spots are dominant and fundamental residues that contribute most of the binding free energy yet accounting for a small portion of protein–DNA interfaces. As experimental methods for identifying hot spots are time-consuming and costly, high-efficiency computational...

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Bibliographic Details
Main Authors: Sijia Zhang, Lihua Wang, Le Zhao, Menglu Li, Mengya Liu, Ke Li, Yannan Bin, Junfeng Xia
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Bioinformatics
Subjects:
Protein–DNA complex
Hot spot
Interfacial neighbor property
Support vector machine
Feature selection
Online Access:https://doi.org/10.1186/s12859-020-03871-1

Internet

https://doi.org/10.1186/s12859-020-03871-1

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