The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions

Even in the absence of strong indications deriving from clinical studies, the removal of mediators is increasingly used in septic shock and in other clinical conditions characterized by a hyperinflammatory response. Despite the different underlying mechanisms of action, they are collectively indicat...

Full description

Bibliographic Details
Main Authors: Giorgio Berlot, Ariella Tomasini, Silvia Zanchi, Edoardo Moro
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/12/5/1723
_version_ 1797615126564569088
author Giorgio Berlot
Ariella Tomasini
Silvia Zanchi
Edoardo Moro
author_facet Giorgio Berlot
Ariella Tomasini
Silvia Zanchi
Edoardo Moro
author_sort Giorgio Berlot
collection DOAJ
description Even in the absence of strong indications deriving from clinical studies, the removal of mediators is increasingly used in septic shock and in other clinical conditions characterized by a hyperinflammatory response. Despite the different underlying mechanisms of action, they are collectively indicated as blood purification techniques. Their main categories include blood- and plasma processing procedures, which can run in a stand-alone mode or, more commonly, in association with a renal replacement treatment. The different techniques and principles of function, the clinical evidence derived from multiple clinical investigations, and the possible side effects are reviewed and discussed along with the persisting uncertainties about their precise role in the therapeutic armamentarium of these syndromes.
first_indexed 2024-03-11T07:22:05Z
format Article
id doaj.art-f489ddcafb834656b448aa012f2fac52
institution Directory Open Access Journal
issn 2077-0383
language English
last_indexed 2024-03-11T07:22:05Z
publishDate 2023-02-01
publisher MDPI AG
record_format Article
series Journal of Clinical Medicine
spelling doaj.art-f489ddcafb834656b448aa012f2fac522023-11-17T07:57:28ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125172310.3390/jcm12051723The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory ConditionsGiorgio Berlot0Ariella Tomasini1Silvia Zanchi2Edoardo Moro3Department of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyDepartment of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyDepartment of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyDepartment of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyEven in the absence of strong indications deriving from clinical studies, the removal of mediators is increasingly used in septic shock and in other clinical conditions characterized by a hyperinflammatory response. Despite the different underlying mechanisms of action, they are collectively indicated as blood purification techniques. Their main categories include blood- and plasma processing procedures, which can run in a stand-alone mode or, more commonly, in association with a renal replacement treatment. The different techniques and principles of function, the clinical evidence derived from multiple clinical investigations, and the possible side effects are reviewed and discussed along with the persisting uncertainties about their precise role in the therapeutic armamentarium of these syndromes.https://www.mdpi.com/2077-0383/12/5/1723septic shocksepsis mediatorshemofiltrationhemoadsorption
spellingShingle Giorgio Berlot
Ariella Tomasini
Silvia Zanchi
Edoardo Moro
The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions
Journal of Clinical Medicine
septic shock
sepsis mediators
hemofiltration
hemoadsorption
title The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions
title_full The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions
title_fullStr The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions
title_full_unstemmed The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions
title_short The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions
title_sort techniques of blood purification in the treatment of sepsis and other hyperinflammatory conditions
topic septic shock
sepsis mediators
hemofiltration
hemoadsorption
url https://www.mdpi.com/2077-0383/12/5/1723
work_keys_str_mv AT giorgioberlot thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions
AT ariellatomasini thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions
AT silviazanchi thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions
AT edoardomoro thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions
AT giorgioberlot techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions
AT ariellatomasini techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions
AT silviazanchi techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions
AT edoardomoro techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions