The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions
Even in the absence of strong indications deriving from clinical studies, the removal of mediators is increasingly used in septic shock and in other clinical conditions characterized by a hyperinflammatory response. Despite the different underlying mechanisms of action, they are collectively indicat...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/12/5/1723 |
_version_ | 1797615126564569088 |
---|---|
author | Giorgio Berlot Ariella Tomasini Silvia Zanchi Edoardo Moro |
author_facet | Giorgio Berlot Ariella Tomasini Silvia Zanchi Edoardo Moro |
author_sort | Giorgio Berlot |
collection | DOAJ |
description | Even in the absence of strong indications deriving from clinical studies, the removal of mediators is increasingly used in septic shock and in other clinical conditions characterized by a hyperinflammatory response. Despite the different underlying mechanisms of action, they are collectively indicated as blood purification techniques. Their main categories include blood- and plasma processing procedures, which can run in a stand-alone mode or, more commonly, in association with a renal replacement treatment. The different techniques and principles of function, the clinical evidence derived from multiple clinical investigations, and the possible side effects are reviewed and discussed along with the persisting uncertainties about their precise role in the therapeutic armamentarium of these syndromes. |
first_indexed | 2024-03-11T07:22:05Z |
format | Article |
id | doaj.art-f489ddcafb834656b448aa012f2fac52 |
institution | Directory Open Access Journal |
issn | 2077-0383 |
language | English |
last_indexed | 2024-03-11T07:22:05Z |
publishDate | 2023-02-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Clinical Medicine |
spelling | doaj.art-f489ddcafb834656b448aa012f2fac522023-11-17T07:57:28ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125172310.3390/jcm12051723The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory ConditionsGiorgio Berlot0Ariella Tomasini1Silvia Zanchi2Edoardo Moro3Department of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyDepartment of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyDepartment of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyDepartment of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyEven in the absence of strong indications deriving from clinical studies, the removal of mediators is increasingly used in septic shock and in other clinical conditions characterized by a hyperinflammatory response. Despite the different underlying mechanisms of action, they are collectively indicated as blood purification techniques. Their main categories include blood- and plasma processing procedures, which can run in a stand-alone mode or, more commonly, in association with a renal replacement treatment. The different techniques and principles of function, the clinical evidence derived from multiple clinical investigations, and the possible side effects are reviewed and discussed along with the persisting uncertainties about their precise role in the therapeutic armamentarium of these syndromes.https://www.mdpi.com/2077-0383/12/5/1723septic shocksepsis mediatorshemofiltrationhemoadsorption |
spellingShingle | Giorgio Berlot Ariella Tomasini Silvia Zanchi Edoardo Moro The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions Journal of Clinical Medicine septic shock sepsis mediators hemofiltration hemoadsorption |
title | The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions |
title_full | The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions |
title_fullStr | The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions |
title_full_unstemmed | The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions |
title_short | The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions |
title_sort | techniques of blood purification in the treatment of sepsis and other hyperinflammatory conditions |
topic | septic shock sepsis mediators hemofiltration hemoadsorption |
url | https://www.mdpi.com/2077-0383/12/5/1723 |
work_keys_str_mv | AT giorgioberlot thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions AT ariellatomasini thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions AT silviazanchi thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions AT edoardomoro thetechniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions AT giorgioberlot techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions AT ariellatomasini techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions AT silviazanchi techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions AT edoardomoro techniquesofbloodpurificationinthetreatmentofsepsisandotherhyperinflammatoryconditions |