Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity

Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity

Amyloid-β precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. APP and sAPP were reported to bind to the extracellular sushi domain 1 (SD1) of GABAB receptors (GBRs). A 17 amino acid peptide (APP17) derived from APP was suff...

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Bibliographic Details
Main Authors: Pascal Dominic Rem, Vita Sereikaite, Diego Fernández-Fernández, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salomé Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Strømgaard, Bernhard Bettler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
GABAB
G protein-coupled receptors
soluble amyloid-β precursor protein
Online Access:https://elifesciences.org/articles/82082

Internet

https://elifesciences.org/articles/82082

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