Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells. Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is fundamental for bioenergetics. Nevertheless, tumor microenvironment is frequently characterized by low-oxygen conditio...

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Bibliographic Details
Main Authors: Vittoria Infantino, Anna Santarsiero, Paolo Convertini, Simona Todisco, Vito Iacobazzi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
HIF-1
cancer metabolism
hypoxia
TCA cycle
mitochondria
Online Access:https://www.mdpi.com/1422-0067/22/11/5703

Internet

https://www.mdpi.com/1422-0067/22/11/5703

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