Development of a novel human intestinal model to elucidate the effect of anaerobic commensals on Escherichia coli infection

Development of a novel human intestinal model to elucidate the effect of anaerobic commensals on Escherichia coli infection

The gut microbiota plays a crucial role in protecting against enteric infection. However, the underlying mechanisms are largely unknown owing to a lack of suitable experimental models. Although most gut commensals are anaerobic, intestinal epithelial cells require oxygen for survival. In addition, m...

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Bibliographic Details
Main Authors: Conor J. McGrath, Edgaras Laveckis, Andrew Bell, Emmanuelle Crost, Nathalie Juge, Stephanie Schüller
Format: Article
Language:English
Published: The Company of Biologists 2022-04-01
Series:Disease Models & Mechanisms
Subjects:
epec
limosilactobacillus reuteri
ruminococcus gnavus
colonization resistance
microbiota
intestinal epithelium
mucus
model system
Online Access:http://dmm.biologists.org/content/15/4/dmm049365

Internet

http://dmm.biologists.org/content/15/4/dmm049365

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