Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

Fifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier to chemotherapeutics by increasing mucins’ secretion. We show that low leve...

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Bibliographic Details
Main Authors: Gerard Cantero-Recasens, Josune Alonso-Marañón, Teresa Lobo-Jarne, Marta Garrido, Mar Iglesias, Lluis Espinosa, Vivek Malhotra
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
chemotherapy
colorectal cancer
mucins
KChIP3
chemoresistance
5-FU+iri.
Online Access:https://elifesciences.org/articles/73926

Internet

https://elifesciences.org/articles/73926

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