SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer

Abstract Background Autophagy is a cell degradation pathway that eliminates damaged or unwanted proteins and organelles. Autophagy protects cells from chemotherapeutic agents by scavenging damaged mitochondria. Methods Plasmid transfection and shRNA were used to regulate SHP-2 expression. Annexin V/...

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Bibliographic Details
Main Authors: Dewen Yan, Danyang Zhu, Xiumin Zhao, Jun Su
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Cancer Cell International
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12935-018-0505-3