SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer
Abstract Background Autophagy is a cell degradation pathway that eliminates damaged or unwanted proteins and organelles. Autophagy protects cells from chemotherapeutic agents by scavenging damaged mitochondria. Methods Plasmid transfection and shRNA were used to regulate SHP-2 expression. Annexin V/...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-01-01
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Series: | Cancer Cell International |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12935-018-0505-3 |