A pilot study showing that repeated exposure to stress produces alterations in subsequent responses to anesthetics in rats.

The repeated use of a drug frequently leads to alterations in the response to that drug. We undertook this study to determine whether multiple exposures to the general anesthetic produced alterations in subsequent exposures to this anesthetic. For this study, adult male rats were anesthetized with 2...

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Bibliographic Details
Main Authors: Lingzhi Wang, Lindsay Holland, Robert Fong, Suhail Khokhar, Aaron P Fox, Zheng Xie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214093