A computational model of stem cells’ decision-making mechanism to maintain tissue homeostasis and organization in the presence of stochasticity

Abstract The maintenance of multi-cellular developed tissue depends on the proper cell production rate to replace the cells destroyed by the programmed process of cell death. The stem cell is the main source of producing cells in a developed normal tissue. It makes the stem cell the lead role in the...

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Bibliographic Details
Main Authors: Najme Khorasani, Mehdi Sadeghi
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12717-0