Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

Abstract Background The development of potent non-toxic chemotherapeutic drugs against castration resistant prostate cancer (CRPC) remains a major challenge. Corosolic acid (CA), a natural triterpenoid, has anti-cancer activity with limited side effects. However, CA anti-prostate cancer activities a...

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Bibliographic Details
Main Authors: Bo Ma, Hang Zhang, Yu Wang, Ang Zhao, Zhiming Zhu, Xiaowen Bao, Yang Sun, Lin Li, Qi Zhang
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Corosolic acid (CA)
Endoplasmic reticulum stress (ER stress)
CCAAT-enhancer-binding protein homologous protein (CHOP)
Tribbles homolog 3 (TRIB3)
Castration resistant PCa (CRPC)
Protein kinase RNA-like endoplasmic reticulum kinase (PERK)
Online Access:http://link.springer.com/article/10.1186/s13046-018-0889-x

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http://link.springer.com/article/10.1186/s13046-018-0889-x

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