Case Report: Subtotal Lymphoid and Total Marrow Irradiation as Bridge Therapy to CD19-Directed CAR T Cells in a Chemorefractory DLBCL With Leukemic Involvement

Case Report: Subtotal Lymphoid and Total Marrow Irradiation as Bridge Therapy to CD19-Directed CAR T Cells in a Chemorefractory DLBCL With Leukemic Involvement

CAR T cell therapy has transformed the salvage approach for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). Maintaining disease control before CAR T cell infusion during product manufacturing (so-called bridging therapy) is an important step to optimizing outcome. Among possible bridg...

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Bibliographic Details
Main Authors: Simonetta Saldi, Vincenzo Maria Perriello, Lorenza Falini, Loredana Ruggeri, Christian Fulcheri, Sara Ciardelli, Alessandra Innocente, Stelvio Ballanti, Nicodemo Baffa, Leonardo Flenghi, Antonio Pierini, Cynthia Aristei, Brunangelo Falini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
CAR (chimeric antigen receptor) T cells
radiotherapy
diffuse large B-cell lymphoma
bridge therapy
gene therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.934700/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.934700/full

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