CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to autism symptoms and macrocephaly by a haploinsufficiency mechanism. However, studi...

Full description

Bibliographic Details
Main Authors: Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, Xiaopeng Luo, Mingtian Pan, Xiusheng Chen, Jiawei Zhang, Huijuan Xu, Xiangyu Guo, Sen Yan, Peng Yin, Zhiguang Zhao, Jianrong Liu, Yafeng Luo, Yuefeng Li, Zhengyi Yang, Baogui Zhang, Zhiqiang Tan, Hao Xu, Tianzi Jiang, Yong-hui Jiang, Shihua Li, Yong Q. Zhang, Xiao-Jiang Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00525-3

Internet

https://doi.org/10.1038/s41421-023-00525-3

Similar Items