Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

Abstract Background Causal associations between microglia activation and β-amyloid (Aβ) accumulation during the progression of Alzheimer’s disease (AD) remain a matter of controversy. Therefore, we used longitudinal dual tracer in vivo small animal positron emission tomography (μPET) imaging to reso...

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Bibliographic Details
Main Authors: Tanja Blume, Carola Focke, Finn Peters, Maximilian Deussing, Nathalie L. Albert, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Laurence Ozmen, Karlheinz Baumann, Peter Bartenstein, Axel Rominger, Jochen Herms, Matthias Brendel
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
TSPO μPET
Amyloid μPET
Alzheimer’s disease
Neuroinflammation
Microglia
Aging
Online Access:http://link.springer.com/article/10.1186/s12974-018-1347-6

Internet

http://link.springer.com/article/10.1186/s12974-018-1347-6

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