Molecular dissection of the E6 PBM identifies essential residues regulating Chk1 phosphorylation and subsequent 14-3-3 recognition

Molecular dissection of the E6 PBM identifies essential residues regulating Chk1 phosphorylation and subsequent 14-3-3 recognition

Previous studies have shown that the high-risk HPV E6 oncoprotein PDZ binding motifs (PBMs) can interact with PDZ proteins or members of the 14-3-3 family, depending upon the E6 phosphorylation status. However, different HPV E6 oncoproteins are subjected to phosphorylation by different cellular kina...

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Bibliographic Details
Main Authors: Arushi Vats, Jayashree V. Thatte, Lawrence Banks
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Tumour Virus Research
Subjects:
HPV
E6
PDZ
Phosphorylation
14-3-3
Online Access:http://www.sciencedirect.com/science/article/pii/S2666679023000046

Internet

http://www.sciencedirect.com/science/article/pii/S2666679023000046

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