Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease

Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disease. It is featured by abnormal alpha-synuclein (α-syn) aggregation in dopaminergic neurons in the substantia nigra. Macroautophagy (autophagy) is an evolutionarily conserved cellular process for degradation of cellular...

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Bibliographic Details
Main Authors: Qi Zhu, Juxian Song, Jia-Yue Chen, Zhenwei Yuan, Liangfeng Liu, Li-Ming Xie, Qiwen Liao, Richard D. Ye, Xiu Chen, Yepiao Yan, Jieqiong Tan, Chris Soon Heng Tan, Min Li, Jia-Hong Lu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Corynoxine B
Parkinson's disease
Neurodegenerative disease
α-Synuclein
Autophagy
PI3KC3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001004

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http://www.sciencedirect.com/science/article/pii/S2211383523001004

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