Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1

Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1

Summary: Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1 activation. Here, we demonstrate that glucose potentiates...

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Bibliographic Details
Main Authors: Eugènia Almacellas, Joffrey Pelletier, Anna Manzano, Antonio Gentilella, Santiago Ambrosio, Caroline Mauvezin, Albert Tauler
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219303797

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http://www.sciencedirect.com/science/article/pii/S2589004219303797

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