Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy

Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy

ABSTRACT: Background: Radiotherapy or accidental exposure to ionizing radiation causes severe damage of healthy intestinal tissues. Intestinal barrier function is highly sensitive to ionizing radiation, and loss of epithelial integrity results in mucosal inflammation, bacterial translocation, and e...

Full description

Bibliographic Details
Main Authors: Seo Young Kwak, Won Il Jang, Seungwoo Park, Sang Sik Cho, Seung Bum Lee, Min-Jung Kim, Sunhoo Park, Sehwan Shim, Hyosun Jang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:EBioMedicine
Subjects:
Radiation-induced enteropathy
Epithelial integrity
Pravastatin
Minipigs
Metallothionein 2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421004345

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421004345

Similar Items