Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and Parkinson’s disease. While constitutive Cdk5 knoc...

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Bibliographic Details
Main Authors: Alan Umfress, Sarbjit Singh, Kevin J. Ryan, Ayanabha Chakraborti, Florian Plattner, Yogesh Sonawane, Jayapal Reddy Mallareddy, Edward P. Acosta, Amarnath Natarajan, James A. Bibb
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
cyclin-dependent kinase 5
pharmacokinetics
inhibitors
behavior
kinase inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.863762/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.863762/full

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