Liquid Biopsy for Proliferative Diabetic Retinopathy: Single-Cell Transcriptomics of Human Vitreous Reveals Inflammatory T-Cell Signature

Liquid Biopsy for Proliferative Diabetic Retinopathy: Single-Cell Transcriptomics of Human Vitreous Reveals Inflammatory T-Cell Signature

Purpose: Current therapies for proliferative diabetic retinopathy (PDR) do not specifically target VEGF-independent, cell-type–specific processes that lead to vision loss, such as inflammatory pathways. This study aimed to identify targetable cell types and corresponding signaling pathways by elucid...

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Bibliographic Details
Main Authors: Rachana Haliyur, MD, PhD, David H. Parkinson, MS, Feiyang Ma, PhD, Jing Xu, PhD, Qiang Li, MD, PhD, Yuanhao Huang, Lam C. Tsoi, PhD, Rachael Bogle, MS, Jie Liu, PhD, Johann E. Gudjonsson, MD, Rajesh C. Rao, MD
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Ophthalmology Science
Subjects:
Proliferative diabetic retinopathy
PDR
Single cell
Vitreous
Pars plana vitrectomy
PPV
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914524000757

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http://www.sciencedirect.com/science/article/pii/S2666914524000757

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