The Nitro Group Reshapes the Effects of Pyrido[3,4-<i>g</i>]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells

The Nitro Group Reshapes the Effects of Pyrido[3,4-<i>g</i>]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells

Serine-threonine protein kinases of the DYRK and CLK families regulate a variety of vital cellular functions. In particular, these enzymes phosphorylate proteins involved in pre-mRNA splicing. Targeting splicing with pharmacological DYRK/CLK inhibitors emerged as a promising anticancer strategy. Inv...

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Bibliographic Details
Main Authors: Sophia S. Borisevich, Tatiana E. Aksinina, Margarita G. Ilyina, Victoria O. Shender, Ksenia S. Anufrieva, Georgij P. Arapidi, Nadezhda V. Antipova, Fabrice Anizon, Yannick J. Esvan, Francis Giraud, Victor V. Tatarskiy, Pascale Moreau, Mikhail I. Shakhparonov, Marat S. Pavlyukov, Alexander A. Shtil
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
pyridoquinazolines
DYRK protein kinases
CLK protein kinases
quantum chemical calculations
gene transcription
RNA splicing
Online Access:https://www.mdpi.com/2072-6694/16/4/834

Internet

https://www.mdpi.com/2072-6694/16/4/834

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