Saponin Micelles Lead to High Mucosal Permeation and In Vivo Efficacy of Solubilized Budesonide

Saponin Micelles Lead to High Mucosal Permeation and In Vivo Efficacy of Solubilized Budesonide

Due to fast nasal mucociliary clearance, only the dissolved drug content can effectively permeate the mucosa and be pharmaceutically active after intranasal application of suspensions. Therefore, the aim of this study was to increase the budesonide concentration in solution of a nasal spray formulat...

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Bibliographic Details
Main Authors: Sabine Nakowitsch, Christiane Koller, Jan-Marcus Seifert, Marielle König-Schuster, Nicole Unger-Manhart, Cornelia Siegl, Norman Kirchoff, Elisabeth Foglar, Christine Graf, Martina Morokutti-Kurz, Marianne Neurath, Svenja Sladek, Christian Knecht, Wolfgang Sipos, Eva Prieschl-Grassauer, Andreas Grassauer
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
solubilization
micelles
inflammation mouse model
drug permeation
local application
tissue availability
Online Access:https://www.mdpi.com/1999-4923/12/9/847

Internet

https://www.mdpi.com/1999-4923/12/9/847

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