Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. miRNases comprise a peptide [(LeuArg)2Gly]2 capable...

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Bibliographic Details
Main Authors: Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
artificial ribonuclease
oligonucleotide-peptide conjugate
RNA cleavage
RNase H
anti-miRNA therapy
miRNA-21
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00879/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00879/full

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