CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

Objective: Enhanced de novo lipogenesis (DNL) in hepatocytes is a major contributor to nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in the pathogenesis of NAFLD through facilitating free fatty acids uptake. Here, we explored the effects of CD36 on DNL and e...

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Bibliographic Details
Main Authors: Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Metabolism
Subjects:
NAFLD
CD36
Lipogenesis
SREBP1 processing
INSIG2
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821002866

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http://www.sciencedirect.com/science/article/pii/S2212877821002866

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