Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer

Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer

Summary: Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted in improved efficacy, even though induction of an e...

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Bibliographic Details
Main Authors: Nada H. Eisa, Vincent M. Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A. Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T.F. Tsai, Paulo C. Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Microenvironment
Biological sciences
Molecular biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223023854

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http://www.sciencedirect.com/science/article/pii/S2589004223023854

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