Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition

Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition

Leptospirosis is a zoonosis caused by spirochetes from the genus Leptospira. This disease is common in tropical and subtropical areas, constituting a serious public health problem. Pathogenic Leptospira have the ability to escape the human Complement System, being able to survive when in contact wit...

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Bibliographic Details
Main Authors: Thais A. Amamura, Tatiana R. Fraga, Sílvio A. Vasconcellos, Angela S. Barbosa, Lourdes Isaac
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
Leptospira
immune evasion
proteases
MAC
complement system
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00958/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00958/full

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