The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors
<p>BRCA1 and BRCA2 mutations are responsible for most familial breast carcinomas. Recent reports carried out in non-cancerous mouse BRCA1- or BRCA2-deficient embryonic stem (ES) cells, and hamster BRCA2-deficient cells have demonstrated that the targeted inhibition of poly(ADP-ribose) polymera...
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Format: | Article |
Language: | English |
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Ivyspring International Publisher
2006-01-01
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Series: | International Journal of Biological Sciences |
Online Access: | http://www.biolsci.org/v02p0179.htm |