Identification and characterization of FGFR2+ hematopoietic stem cell-derived fibrocytes as precursors of cancer-associated fibroblasts induced by esophageal squamous cell carcinoma

Identification and characterization of FGFR2+ hematopoietic stem cell-derived fibrocytes as precursors of cancer-associated fibroblasts induced by esophageal squamous cell carcinoma

Abstract Background Cancer-associated fibroblast (CAF) is an ideal target for cancer treatment. Recent studies have focused on eliminating CAFs and their effects by targeting their markers or blocking individual CAF-secreted factors. However, these strategies have been limited by their specificity f...

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Bibliographic Details
Main Authors: Haibo Qiu, Xu Zhang, Jiali Qi, Jiangwen Zhang, Yin Tong, Lei Li, Li Fu, Yan-Ru Qin, Xinyuan Guan, Liyi Zhang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CAF
FGFR2
CAF mobilization
CAF recruitment
CAF maturation
FGF2
Online Access:https://doi.org/10.1186/s13046-022-02435-w

Internet

https://doi.org/10.1186/s13046-022-02435-w

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