Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

Abstract Accumulating evidence has implicated impaired extracellular matrix (ECM) clearance as a key factor in fibrotic disease. Despite decades of research elucidating the effectors of ECM clearance, relatively little is understood regarding the upstream regulation of this process. Collagen is the...

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Bibliographic Details
Main Authors: Michael J. Podolsky, Benjamin Kheyfets, Monika Pandey, Afaq H. Beigh, Christopher D. Yang, Carlos O. Lizama, Ritwik Datta, Liangguang L. Lin, Zhihong Wang, Paul J. Wolters, Michael T. McManus, Ling Qi, Kamran Atabai
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45817-8

Internet

https://doi.org/10.1038/s41467-024-45817-8

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