Dalcetrapib and anacetrapib increase apolipoprotein E-containing HDL in rabbits and humans

Dalcetrapib and anacetrapib increase apolipoprotein E-containing HDL in rabbits and humans

The large HDL particles generated by administration of cholesteryl ester transfer protein inhibitors (CETPi) remain poorly characterized, despite their potential importance in the routing of cholesterol to the liver for excretion, which is the last step of the reverse cholesterol transport. Thus, th...

Full description

Bibliographic Details
Main Authors:	Mathieu R. Brodeur, David Rhainds, Daniel Charpentier, Marie Boulé, Téodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Valérie Pedneault-Gagnon, Annik Fortier, Eric J. Niesor, Eric Rhéaume, Cyrille Maugeais, Jean-Claude Tardif
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Series:	Journal of Lipid Research
Subjects:	CETP cholesteryl ester transfer protein inhibitors apolipoprotein composition low-density lipoprotein receptor atorvastatin dal-PLAQUE-2 study
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227522001493

Similar Items

Dalcetrapib and anacetrapib differently impact HDL structure and function in rabbits and monkeys
by: Mathieu R. Brodeur, et al.
Published: (2017-07-01)

Improved Synthesis and Crystal Structure of Dalcetrapib
by: Frank Richter, et al.
Published: (2012-10-01)

Dissecting the Structural Dynamics of Authentic Cholesteryl Ester Transfer Protein for the Discovery of Potential Lead Compounds: A Theoretical Study
by: Yizhen Zhao, et al.
Published: (2023-07-01)

Cholesteryl ester transfer protein:Ace of Spades, Queen of Hearts, or The Joker?
by: Norman Eric Miller
Published: (2015-07-01)

HDL Receptor in Schistosoma japonicum Mediating Egg Embryonation: Potential Molecular Basis for High Prevalence of Cholesteryl Ester Transfer Protein Deficiency in East Asia
by: Shinji Yokoyama
Published: (2022-03-01)

A Molecular and Biochemical Study for Cholesteryl Ester Transfer Protein (CETP) Taq1B in Iraqi Patients with Hyperlipidemia
by: Alkhafajy et al.
Published: (2019-09-01)

Simultaneous transfer of cholesterol, triglycerides, and phospholipids to high-density lipoprotein in aging subjects with or without coronary artery disease
by: Carolina H. M Azevedo, et al.
Published: (2011-01-01)

Study of Cholesteryl Ester Transfer Protein (CETP) I405v Genotype and Its Association with Lipid Fractions in Myocardial Infarction Patients: A Case Control Study
by: Prakash D. Zende, et al.
Published: (2014-06-01)

TaqI B1/B2 and -629A/C cholesteryl ester transfer protein (CETP) gene polymorphisms and their association with CETP activity and high-density lipoprotein cholesterol levels in a Tehranian population. Part of the Tehran Lipid and Glucose Study (TLGS)
by: Maryam S Daneshpour, et al.
Published: (2007-01-01)

Anacetrapib, a New CETP Inhibitor: The New Tool for the Management of Dyslipidemias?
by: Theodosios D. Filippatos, et al.
Published: (2017-09-01)

In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption
by: Sheng-Ping Wang, et al.
Published: (2013-10-01)

Inhibition of the 3CL Protease and SARS-CoV‑2 Replication by Dalcetrapib
by: Eric J Niesor, et al.
Published: (2021-06-01)

Serum Cholesteryl Ester Transfer Protein (CETP) and Sortilin (SORT) in Patients with Psoriasis with Relation to Systemic Treatment
by: Julia Nowowiejska, et al.
Published: (2022-04-01)

CETP inhibitor evacetrapib enters mouse brain tissue
by: Jasmine Phénix, et al.
Published: (2023-07-01)

Sources of eicosanoid precursor fatty acid pools in tissues
by: Li Zhou, et al.
Published: (2001-10-01)

Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib
by: Ronald M. Krauss, et al.
Published: (2012-03-01)

Effect of Anacetrapib on Cholesterol Efflux Capacity: A Substudy of the DEFINE Trial
by: Mark P. Metzinger, et al.
Published: (2020-12-01)

Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux[S]
by: David G. McLaren, et al.
Published: (2016-03-01)

Atorvastatin improves cisplatin sensitivity through modulation of cholesteryl ester homeostasis in breast cancer cells
by: Diandra Zipinotti dos Santos, et al.
Published: (2022-12-01)

Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters
by: Jose Castro-Perez, et al.
Published: (2011-11-01)

Low‐density lipoprotein receptor is required for cholesteryl ester transfer protein to regulate triglyceride metabolism in both male and female mice
by: Brian T. Palmisano, et al.
Published: (2021-02-01)

Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin[S]
by: Susan Kühnast, et al.
Published: (2014-10-01)

Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E[S]
by: John S. Millar, et al.
Published: (2017-06-01)

Expression of simian CETP in normolipidemic Fisher rats has a profound effect on large sized apoE-containing HDL
by: Zoulika Zak, et al.
Published: (2002-12-01)

Hyperalphalipoproteinemia and Beyond: The Role of HDL in Cardiovascular Diseases
by: Antonina Giammanco, et al.
Published: (2021-06-01)

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9[S]
by: Sam J.L. van der Tuin, et al.
Published: (2015-11-01)

Cooperation between hepatic cholesteryl ester hydrolase and scavenger receptor BI for hydrolysis of HDL-CE
by: Quan Yuan, et al.
Published: (2013-11-01)

Quantitative Prediction of Human Pharmacokinetics and Pharmacodynamics of CKD519, a Potent Inhibitor of Cholesteryl Ester Transfer Protein (CETP)
by: Suein Choi, et al.
Published: (2019-07-01)

Improving Security of Future Networks Using Enhanced Customer Edge Switching and Risk-Based Analysis
by: Slawomir Nowaczewski, et al.
Published: (2021-05-01)

A Population Pharmacokinetic and Pharmacodynamic Model of CKD-519
by: Choon Ok Kim, et al.
Published: (2020-06-01)

Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
by: Jing-Kang Shen, et al.
Published: (2012-05-01)

Obesity Affects HDL Metabolism, Composition and Subclass Distribution
by: Julia T. Stadler, et al.
Published: (2021-02-01)

Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion
by: Jessica Lie, et al.
Published: (2002-11-01)

Influence of Genes on the Lifespan of Long- and Short-Lived Families
by: Vana Kolovou, MSc, PhD student
Published: (2017-05-01)

New molecular insights into CETP structure and function: a review
by: M. Arthur Charles, et al.
Published: (2012-08-01)

Cholesterol biosynthesis in transplantable hepatomas: evidence for impairment of uptake and storage of dietary cholesterol
by: D.S. HARRY, et al.
Published: (1971-05-01)

Optimisation of reference genes for gene-expression analysis in a rabbit model of left ventricular diastolic dysfunction.
by: Walid Nachar, et al.
Published: (2014-01-01)

Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels
by: Hinds David A, et al.
Published: (2004-11-01)

Novel Role of CETP in Macrophages: Reduction of Mitochondrial Oxidants Production and Modulation of Cell Immune-Metabolic Profile
by: Gabriel G. Dorighello, et al.
Published: (2022-08-01)

Impacts of seasonal variations and wastewater discharge on river quality and associated human health risks: A case of northwest Dhaka, Bangladesh
by: Hazzaz Bin Hassan, et al.
Published: (2023-07-01)