Modelling Metabolic Shifts during Cardiomyocyte Differentiation, Iron Deficiency and Transferrin Rescue Using Human Pluripotent Stem Cells

Modelling Metabolic Shifts during Cardiomyocyte Differentiation, Iron Deficiency and Transferrin Rescue Using Human Pluripotent Stem Cells

Cardiomyocytes rely on specialised metabolism to meet the high energy demand of the heart. During heart development, metabolism matures and shifts from the predominant utilisation of glycolysis and glutamine oxidation towards lactate and fatty acid oxidation. Iron deficiency (ID) leads to cellular m...

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Bibliographic Details
Main Authors: Benjamin B. Johnson, Johannes Reinhold, Terri L. Holmes, Jamie A. Moore, Verity Cowell, Andreia S. Bernardo, Stuart A. Rushworth, Vassilios Vassiliou, James G. W. Smith
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Metabolites
Subjects:
iron deficiency
cardiomyocytes
pluripotent stem cells
Online Access:https://www.mdpi.com/2218-1989/12/1/9

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https://www.mdpi.com/2218-1989/12/1/9

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