Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance

Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance

Abstract Islet β cell dysfunction and insulin resistance are the main pathogenesis of type 2 diabetes (T2D), but the mechanism remains unclear. Here we identify a rs3819316 C > T mutation in lncRNA Reg1cp mainly expressed in islets associated with an increased risk of T2D. Analyses in 16,113 Chin...

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Bibliographic Details
Main Authors: Wan-Hui Guo, Qi Guo, Ya-Lin Liu, Dan-Dan Yan, Li Jin, Rong Zhang, Jing Yan, Xiang-Hang Luo, Mi Yang
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05348-w

Internet

https://doi.org/10.1038/s41419-022-05348-w

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