The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons.

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons.

Herpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced. The only highly expressed viral gene product during latent infection is the latency-associated transcript (LAT), a non-protein coding RNA that has been...

Full description

Bibliographic Details
Main Authors: Michael P Nicoll, William Hann, Maitreyi Shivkumar, Laura E R Harman, Viv Connor, Heather M Coleman, João T Proença, Stacey Efstathiou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4824392?pdf=render

Internet

http://europepmc.org/articles/PMC4824392?pdf=render

Similar Items