Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

Summary: Antibodies targeting the V1V2 apex of the HIV-1 envelope (Env) trimer comprise one of the most commonly elicited categories of broadly neutralizing antibodies. Structures of these antibodies indicate diverse modes of Env recognition typified by antibodies of the PG9 class and the PGT145 cla...

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Bibliographic Details
Main Authors: Jason Gorman, Gwo-Yu Chuang, Yen-Ting Lai, Chen-Hsiang Shen, Jeffrey C. Boyington, Aliaksandr Druz, Hui Geng, Mark K. Louder, Krisha McKee, Reda Rawi, Raffaello Verardi, Yongping Yang, Baoshan Zhang, Nicole A. Doria-Rose, Bob Lin, Penny L. Moore, Lynn Morris, Lawrence Shapiro, John R. Mascola, Peter D. Kwong
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720303661

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http://www.sciencedirect.com/science/article/pii/S2211124720303661

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