Oral Preconditioning of Donors After Brain Death With Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation

Oral Preconditioning of Donors After Brain Death With Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation

Background: The systemic inflammatory cascade triggered in donors after brain death enhances the ischemia-reperfusion injury after organ transplantation. Intravenous steroids are routinely used in the intensive care units for the donor preconditioning. Immunosuppressive medications could be potentia...

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Bibliographic Details
Main Authors: Sepehr Abbasi Dezfouli, Mohammadsadegh Nikdad, Omid Ghamarnejad, Elias Khajeh, Alireza Arefidoust, Sara Mohammadi, Ali Majlesara, Mohammadsadegh Sabagh, Negin Gharabaghi, Modar Kentar, Alexander Younsi, Christoph Eckert, Tanja Poth, Mohammad Golriz, Arianeb Mehrabi, Arash Nickkholgh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
oral preconditioning
brain death donor
kidney transplantation
pig
calcineurin inhibitors
inhibitors of mammalian target for rapamycin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01222/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01222/full

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