Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway

Abstract Although there are many studies on the relationship between genetic polymorphisms and the incidence of diseases, mechanisms are rarely known. We report the mechanism by which signal transducer and activator of transcription 4 (stat4) rs7574865 promotes the occurrence and progression of hepa...

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Bibliographic Details
Main Authors: Caie Wang, Na Gao, Lukui Yang, Yuanyuan Guo, Yan Fang, Tong Wang, Chen Xu, Gui fang Li, Jun Zhou, Yunfei Zhang, Qiang Wen, Hailing Qiao
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04584-4