E2 Partner Tunes the Ubiquitylation Specificity of Arkadia E3 Ubiquitin Ligase

E2 Partner Tunes the Ubiquitylation Specificity of Arkadia E3 Ubiquitin Ligase

Arkadia (<i>RNF111</i>) is a positive regulator of the TGF-<i>β</i> signaling that mediates the proteasome-dependent degradation of negative factors of the pathway. It is classified as an E3 ubiquitin ligase and a SUMO-targeted ubiquitin ligase (STUBL), implicated in various...

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Bibliographic Details
Main Authors: Georgia N. Delegkou, Maria Birkou, Nefeli Fragkaki, Tamara Toro, Konstantinos D. Marousis, Vasso Episkopou, Georgios A. Spyroulias
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
Arkadia
RING domain
E2 enzymes
ubiquitylation
NMR spectroscopy
Online Access:https://www.mdpi.com/2072-6694/15/4/1040

Internet

https://www.mdpi.com/2072-6694/15/4/1040

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