P53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and ATP synthesis through its target genes

P53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and ATP synthesis through its target genes

P53, a well-known tumor suppressor, has been confirmed to regulate the infection of various viruses, including chicken viruses. Our previous study observed antiviral effect of p53 inhibitor Pifithrin-α (PFT-α) on the infection of avian infectious laryngotracheitis virus (ILTV), one of the major avia...

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Bibliographic Details
Main Authors: Li Xu, Zhijie Chen, Yu Zhang, Lu Cui, Zheyi Liu, Xuefeng Li, Shengwang Liu, Hai Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
alphaherpesviruses
P53
PFT-α
virus-host interactions
virus replication
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1044141/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1044141/full

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