Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress

Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress

A key reason for the persistently grim statistics associated with metastatic ovarian cancer is resistance to conventional agents, including platinum-based chemotherapies. A major source of treatment failure is the high degree of genetic and molecular heterogeneity, which results from significant und...

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Bibliographic Details
Main Authors: Shubhankar Nath, Michael Pigula, Amjad P. Khan, William Hanna, Mustafa Kemal Ruhi, Farzaneh Mahmoodpoor Dehkordy, Karthik Pushpavanam, Kaushal Rege, Kaitlin Moore, Yujiro Tsujita, Christina Conrad, Fatih Inci, Marcela G. del Carmen, Walfre Franco, Jonathan P. Celli, Utkan Demirci, Tayyaba Hasan, Huang-Chiao Huang, Imran Rizvi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Journal of Clinical Medicine
Subjects:
ovarian cancer
epidermal growth factor receptor (EGFR)
mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK)
extracellular signal-regulated kinase (ERK)
chemoresistance
fluid shear stress
Online Access:https://www.mdpi.com/2077-0383/9/4/924

Internet

https://www.mdpi.com/2077-0383/9/4/924

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