A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope

A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a receptor on T cells that inhibits the cell’s functions. Blocking CTLA-4 with an antibody has proven effective for the treatment of cancer patients. Anti-CTLA-4 antibodies currently approved for clinical use can bind to human CTLA-4, bu...

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Bibliographic Details
Main Authors: Dong Li, Jing Li, Huanyu Chu, Zhuozhi Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)
CD152
antibody
cross-species binding
epitope mapping
N-glycosylation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1725365

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2020.1725365

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