New Membrane Active Antibacterial and Antiviral Amphiphiles Derived from Heterocyclic Backbone of Pyridinium-4-Aldoxime

New Membrane Active Antibacterial and Antiviral Amphiphiles Derived from Heterocyclic Backbone of Pyridinium-4-Aldoxime

Quaternary ammonium salts (QAS) are irreplaceable membrane-active antimicrobial agents that have been widely used for nearly a century. Cetylpyridinium chloride (CPC) is one of the most potent QAS. However, recent data from the literature indicate that CPC activity against resistant bacterial strain...

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Bibliographic Details
Main Authors: Doris Crnčević, Lucija Krce, Mislav Cvitković, Zlatko Brkljača, Antonio Sabljić, Elma Vuko, Ines Primožič, Renata Odžak, Matilda Šprung
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceuticals
Subjects:
quaternary ammonium salts
pyridinium-4-aldoxime
antimicrobial activity
cytotoxicity
mode of action mechanism
Online Access:https://www.mdpi.com/1424-8247/15/7/775

Internet

https://www.mdpi.com/1424-8247/15/7/775

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