NPD-0414-2 and NPD-0414-24, Two Chemical Entities Designed as Aryl Hydrocarbon Receptor (AhR) Ligands, Inhibit Gut Inflammatory Signals

NPD-0414-2 and NPD-0414-24, Two Chemical Entities Designed as Aryl Hydrocarbon Receptor (AhR) Ligands, Inhibit Gut Inflammatory Signals

Defects in counterregulatory mechanisms contribute to amplify the detrimental inflammatory response leading to the pathologic process occurring in the gut of patients with Crohn’s disease (CD) and ulcerative colitis (UC), the major inflammatory bowel diseases (IBDs), in human beings. One such mechan...

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Bibliographic Details
Main Authors: Irene Marafini, Davide Di Fusco, Vincenzo Dinallo, Eleonora Franzè, Carmine Stolfi, Giuseppe Sica, Giovanni Monteleone, Ivan Monteleone
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
AhR
Ficz
IBD
Crohn’s disease
ulcerative colitis
Il-22
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00380/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00380/full

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