Intestinal Uptake of 6(R)-L-erythro-Tetrahydrobiopterin is Distinct from the Liver-Type MTX-Sensitive Accumulation Process

In order to increase the tissue level of tetrahydrobiopterin (BH4 ) , supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the profile of BH4 accumulation was compared between the liver and the small intestine after feeding with 10mg/kg of 6RBH4 or 7,8-dihydrob...

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Bibliographic Details
Main Authors: Sawabe Keiko, Suetake Yasuko, Wakasugi Kazunori Osuke, Hasegawa Hiroyuki
Format: Article
Language:English
Published: De Gruyter 2005-02-01
Series:Pteridines
Subjects:
Online Access:https://doi.org/10.1515/pteridines.2005.16.1.6