Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS

Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS

Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-κB via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor 4 and its coreceptor, MD-2, results in production of pro-inf...

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Bibliographic Details
Main Authors: Constance M. John, Nancy J. Phillips, Gary A. Jarvis
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Lipid Research
Subjects:
bacterial membranes
glycolipids
inflammation
tandem mass spectrometry
phosphate
phosphoethanol-amine
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520437319

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http://www.sciencedirect.com/science/article/pii/S0022227520437319

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