Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway

Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway

Repetitive intermittent hyperglycemia (RIH) is an independent risk factor for complications associated with type-2 diabetes (T2D). Glucose fluctuations commonly occur in T2D patients with poor glycemic control or following intensive therapy. Reducing blood glucose as well as glucose fluctuations is...

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Bibliographic Details
Main Authors: Fatema Al-Rashed, Sardar Sindhu, Hossein Arefanian, Ashraf Al Madhoun, Shihab Kochumon, Reeby Thomas, Sarah Al-Kandari, Abdulwahab Alghaith, Texy Jacob, Fahd Al-Mulla, Rasheed Ahmad
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
repetitive intermittent hyperglycemia
glucose fluctuations
IRF5
TLR4
macrophages
type-2 diabetes
Online Access:https://www.mdpi.com/2073-4409/9/8/1892

Internet

https://www.mdpi.com/2073-4409/9/8/1892

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