Spontaneous Generation of Infectious Prion Disease in Transgenic Mice

Spontaneous Generation of Infectious Prion Disease in Transgenic Mice

We generated transgenic mice expressing bovine cellular prion protein (PrPC) with a leucine substitution at codon 113 (113L). This protein is homologous to human protein with mutation 102L, and its genetic link with Gerstmann–Sträussler–Scheinker syndrome has been established. This mutation in bovin...

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Bibliographic Details
Main Authors: Juan-María Torres, Joaquín Castilla, Belén Pintado, Alfonso Gutiérrez-Adan, Olivier Andréoletti, Patricia Aguilar-Calvo, Ana-Isabel Arroba, Beatriz Parra-Arrondo, Isidro Ferrer, Jorge Manzanares, Juan-Carlos Espinosa
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2013-12-01
Series:Emerging Infectious Diseases
Subjects:
prions and related diseases
spontaneous generation
transmissible spongiform encephalitis
TSE
bovine spongiform encephalitis
BSE
Online Access:https://wwwnc.cdc.gov/eid/article/19/12/13-0106_article

Internet

https://wwwnc.cdc.gov/eid/article/19/12/13-0106_article

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