Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Abstract Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of sy...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Valentina Latina, Giacomo Giacovazzo, Federica Cordella, Bijorn Omar Balzamino, Alessandra Micera, Monica Varano, Cristina Marchetti, Francesca Malerba, Rita Florio, Bruno Bruni Ercole, Federico La Regina, Anna Atlante, Roberto Coccurello, Silvia Di Angelantonio, Pietro Calissano, Giuseppina Amadoro
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: BMC 2021-03-01
মালা:Acta Neuropathologica Communications
বিষয়গুলি:
Alzheimer’s Disease
Β-amyloid
Mouse model
Neurodegeneration
Retina
Tau
অনলাইন ব্যবহার করুন:https://doi.org/10.1186/s40478-021-01138-1

আন্তর্জাল

https://doi.org/10.1186/s40478-021-01138-1

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