Interferon-β modulates microglial polarization to ameliorate delayed tPA-exacerbated brain injury in ischemic stroke

Interferon-β modulates microglial polarization to ameliorate delayed tPA-exacerbated brain injury in ischemic stroke

Tissue plasminogen activator (tPA) is the only FDA-approved drug for the treatment of ischemic stroke. Delayed tPA administration is associated with increased risks of blood-brain barrier (BBB) disruption and hemorrhagic transformation. Studies have shown that interferon beta (IFNβ) or type I IFN re...

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Détails bibliographiques
Auteurs principaux: Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Paul Bojrab, Brandon Kimes, I-Chen Ivorine Yu, Jui-Hung Jimmy Yen
Format: Article
Langue:English
Publié: Frontiers Media S.A. 2023-03-01
Collection:Frontiers in Immunology
Sujets:
tissue plasminogen activator
interferon beta
type I interferon receptor
blood brain barrier
microglial polarization
ischemic stroke
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148069/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148069/full

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