FUSION-Guided Hypothesis Development Leads to the Identification of N6,N6-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor

FUSION-Guided Hypothesis Development Leads to the Identification of N6,N6-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor

Chemicals found in nature have evolved over geological time scales to productively interact with biological molecules, and thus represent an effective resource for pharmaceutical development. Marine-derived bacteria are rich sources of chemically diverse, bioactive secondary metabolites, but harness...

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Bibliographic Details
Main Authors: Rachel M. Vaden, Nathaniel W. Oswald, Malia B. Potts, John B. MacMillan, Michael A. White
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Marine Drugs
Subjects:
dimethyladenosine
AKT
functional signature ontology
Online Access:http://www.mdpi.com/1660-3397/15/3/75

Internet

http://www.mdpi.com/1660-3397/15/3/75

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